Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole‐Blood Transcriptomics Data
This study advances the understanding of transcriptomic alterations in RA treatment and enhances our understanding of treatment response mechanisms. Although the gene signatures identified require independent replication, the study serves as a starting point to pave the way for personalized therapeutic strategies in patients commencing TNFi therapy in RA.
Authors
- Nisha Nair (ORCID: https://orcid.org/0000-0001-9829-792X)
- Darren Plant (ORCID: https://orcid.org/0000-0003-1395-9344)
- Ann W Morgan (ORCID: https://orcid.org/0000-0003-1109-624X)
- Anne C Barton (ORCID: https://orcid.org/0000-0003-3316-2527)
- Kimme Leanne Hyrich (ORCID: https://orcid.org/0000-0001-8242-9262)
- Guillermo Barturen (ORCID: https://orcid.org/0000-0003-2103-1028)
- John D. Isaacs (ORCID: https://orcid.org/0000-0002-6103-7056)
- Marta E. Alarcón‐Riquelme (ORCID: https://orcid.org/0000-0002-7632-4154)
- Anthony G. Wilson (ORCID: https://orcid.org/0000-0003-4855-3926)
- Chuan Fu Yap (ORCID: https://orcid.org/0000-0001-5256-5642)
- Ivo Glynne Gut (ORCID: https://orcid.org/0000-0001-7219-632X)
- Marta Ortova Gut (ORCID: https://orcid.org/0000-0002-4063-7159)
- María Riva‐Torrubia
Institutions
- University College Dublin (IE)
- University of Leeds (GB)
- Universidad de Granada (ES)
- Leeds Teaching Hospitals NHS Trust (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- Arthritis UK (GB)
- NIHR Newcastle Biomedical Research Centre (GB)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Centro Nacional de Análisis Genómico (ES)
- Parque Tecnológico de la Salud (ES)
- NIHR Manchester Biomedical Research Centre (GB)
- Universitat de Barcelona (ES)
- Newcastle University (GB)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1002/art.43255
- Citations
- 3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- European Federation of Pharmaceutical Industries and Associations
- National Institute for Health and Care Research
- European Commission
- Generalitat de Catalunya
- Versus Arthritis
- Manchester Biomedical Research Centre
- NIHR Newcastle Biomedical Research Centre
- Leeds Biomedical Research Centre