Study on the Extraction Process and Pharmacological Activity of Gentiopicroside from Gentiana

Gentiopicroside, as a representative substance among monoterpenoid compounds, is the main active ingredient in Gentianaceae plants. It can accelerate gastric emptying efficiency and enhance intestinal motility in the digestive system. In pharmacological studies, it also shows effects on protecting liver cells, inhibiting pain and inflammation. The brachychronic liver damage experiment in mouse was set up by inducing carbon tetrachloride CCI4. The activity changes of serum alanine aminotransferase (ALT) and glutathione aminotransferase (AST) were measured. The liveness of philothion peroxisome (GSH-Px), peroxide dismutase (SOD) and malondialdehyde (MDA) details were prepared by liver tissue homogenate. The liveness intensity of serum ALT and AST in the liver of mice in each treatment group was compared from high to low. The liveness of GSH and SOD in liver tissue homogenate increased to varying degrees, and the content of MDA decreased to varying degrees. The study showed that gentiopicroside has a clear defend affect on acute liver damage abduction by CCI4. Its mechanism of action may involve inhibiting free radical-mediated lipid peroxidation and effectively maintaining the functional stability of the antioxidant enzyme system of hepatocytes.