Development of human targeted extracellular vesicles loaded with shRNA minicircles to prevent parkinsonian pathology
Our study confirmed the therapeutic potential of shRNA-MCs delivered by human RVG-EVs for long-term treatment of neurodegenerative diseases. These results pave the way for clinical use of this approach.
Authors
- Josune Garcı́a-Sanmartı́n (ORCID: https://orcid.org/0000-0003-4391-5537)
- Marco Schmeer
- Lydia Alvarez‐Erviti (ORCID: https://orcid.org/0000-0002-1238-9442)
- Estefanía Carlos
- Alejandro Reinares-Sebastián (ORCID: https://orcid.org/0000-0003-1632-4432)
- María de Toro (ORCID: https://orcid.org/0000-0003-3329-0203)
- María Izco (ORCID: https://orcid.org/0000-0003-4807-6779)
- Guglielmo Verona (ORCID: https://orcid.org/0000-0001-8100-3876)
- Enrique Santamaría (ORCID: https://orcid.org/0000-0001-8046-8102)
- Joaquín Fernández‐Irigoyen (ORCID: https://orcid.org/0000-0001-5072-4099)
- Carme Solà (ORCID: https://orcid.org/0000-0002-4012-816X)
- Javier Blesa (ORCID: https://orcid.org/0000-0002-4257-1325)
- María Eugenia Marzo-Sola
- Martin Schleef
- Rodolfo Mugica-Vidal
- Sandra Colina
Institutions
- Universidad de La Rioja (ES)
- Bielefeld University (DE)
- Navarrabiomed (ES)
- HM Hospitales (ES)
- University Hospital HM Puerta del Sur (ES)
- Hospital San Pedro (ES)
- Center for Biomedical Research of La Rioja (ES)
- Roland Hill (United Kingdom) (GB)
- University College London (GB)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s40035-025-00484-7
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Instituto de Salud Carlos III