The topography of infratentorial lesions in depression and anxiety in multiple sclerosis
Depression in multiple sclerosis is associated with lesions within serotoninergic and noradrenergic brainstem nuclei. No definitive anatomical substrate for anxiety was identified. These findings suggest that inflammatory structural changes may underlie mood disorders in multiple sclerosis, potentially serving as early imaging markers of susceptibility to depression.
Authors
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- Flavia Baccari (ORCID: https://orcid.org/0000-0002-2148-9664)
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Stefanie Roberts (ORCID: https://orcid.org/0000-0001-8969-7577)
- Alessandra Lugaresi (ORCID: https://orcid.org/0000-0003-2902-5589)
- Federica Giofrè
- Elaine Lui (ORCID: https://orcid.org/0000-0001-6955-1140)
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1007/s00415-025-13167-0
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- University of Melbourne