Disseminated candidiasis on FDG-PET/CT

Disseminated candidiasis presents a significant diagnostic and therapeutic challenge in immunocompromised patients, particularly those with hematological malignancies like leukemia. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) is a crucial imaging modality in oncology and infection, outperforming conventional imaging in diagnosing and managing fungal infections, especially in cases of fever of unknown origin. We present a compelling case of a young leukemia patient with persistent fever, demonstrating FDG-avid lesions in various organs, including the liver, spleen, and left kidney, indicative of disseminated candidiasis.This highlights the critical role of ¹⁸F-FDG-PET/CT in situations where invasive procedures like liver biopsy are challenging or contraindicated. Such instances underscore the paramount importance of utilizing advanced imaging techniques for accurate diagnosis and treatment, especially in the complex clinical setting of immunocompromised individuals, with hematological malignancies. This case emphasizes the significant contribution of ¹⁸F-FDG-PET/CT as a non-invasive diagnostic tool, enhancing patient care and enabling more effective management strategies amidst challenging medical circumstances.