Association between PAI-1 gene − 657 4G/5G polymorphism and preeclampsia in Egyptian women: a case-control study

Pre-eclampsia constitutes a pregnancy disease characterized by hypertension and proteinuria, as well as dysregulation of the coagulation cascade and hypo fibrinolysis that affects many systems. The purpose of this study is to examine the connection between (-657 4G/5G PAI-1) and the danger of preeclampsia in Egyptian females. A case-control study included 140 Egyptian pregnant women with PE along with 100 normotensive women. The study includes extracting genomic DNA from blood, detecting SNP with ARMS-PCR, and assessing metabolic parameters with serum samples. The study discovered significant variations in PAI-1 5G/4G polymorphism between sufferers and the control group in general (P < 0.001), dominant (P = 0.004), and recessive models (P = 0.009). Pre-eclamptic women had lower SOD activity and GSH levels but higher MDA and GPx activities than the normotensive pregnant group. CONCLUSION: This study indicated that the - 657 4G/5G PAI-I mutation is substantially linked to the development of PE in Egyptian women.