Comparative Cardiovascular Safety of Nonsteroidal Anti‐Inflammatory Drug Versus Colchicine Use When Initiating Urate‐Lowering Therapy Among Patients With Gout: Target Trial Emulations
In these target trial emulations of patients with gout starting allopurinol, NSAID prophylaxis was associated with a higher risk of MACE than colchicine or no prophylaxis, suggesting the avoidance of NSAID for gout flare prophylaxis.
Authors
- Sharan Rai
- J. Antonio Aviña‐Zubieta (ORCID: https://orcid.org/0000-0001-5526-663X)
- Gregory J. Challener (ORCID: https://orcid.org/0000-0002-2844-4661)
- Yuqing Zhang (ORCID: https://orcid.org/0000-0001-7638-0888)
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Natalie McCormick (ORCID: https://orcid.org/0000-0002-4147-8348)
- Chio Yokose (ORCID: https://orcid.org/0000-0001-7557-3303)
- Edoardo Cipolletta (ORCID: https://orcid.org/0000-0002-6881-8197)
- Sridevi Chigurupati (ORCID: https://orcid.org/0000-0002-1081-2964)
- Angelo Gaffo (ORCID: https://orcid.org/0000-0001-7365-7212)
- Hyon K. Choi (ORCID: https://orcid.org/0000-0002-2862-0442)
- Abhishek Abhishek (ORCID: https://orcid.org/0000-0003-0121-4919)
- Na Lu (ORCID: https://orcid.org/0000-0001-5181-7879)
- K. L. Tan
- Bohang Jiang
Institutions
- Marche Polytechnic University (IT)
- Harvard University (US)
- University of British Columbia (CA)
- University of Nottingham (GB)
- University of Alabama at Birmingham (US)
- Massachusetts General Hospital (US)
- Research Canada (CA)
- Baim Institute for Clinical Research (US)
- Birmingham VA Medical Center (US)
- Arthritis Research Centre of Canada (CA)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1002/art.43259
- Citations
- 5
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 7.15
Funders
- National Institutes of Health
- Canadian Institutes of Health Research