Simultaneous Determination of Unbound Plasma Concentration of Methotrexate and 7-Hydroxymethotrexate in Children Patients Receiving High-Dose Methotrexate Therapy
The total concentration of 7-OH-MTX is an unreliable predictor of unbound concentration, necessitating the monitoring of unbound levels. The concentration ratios of 7-OH-MTX to MTX (both total and unbound) could be more accurate and sensitive biomarkers for predicting hepatotoxicity.
Authors
- Shuaishuai Gao (ORCID: https://orcid.org/0000-0003-3534-6215)
- Weichong Dong (ORCID: https://orcid.org/0000-0003-1605-644X)
- Ye Jiang (ORCID: https://orcid.org/0000-0003-0507-8520)
- Bo Shi
- Haoran Li (ORCID: https://orcid.org/0000-0001-5108-9218)
- Yingze Zhang (ORCID: https://orcid.org/0000-0001-8042-6105)
- Jia-Liang Guo
- Zhiqing Zhang (ORCID: https://orcid.org/0000-0001-5871-6499)
Institutions
- Hebei Medical University (CN)
- Nankai University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s516431
- Citations
- 4
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Natural Science Foundation of Hebei Province
- Hebei Medical University