Optimizing CNN-Based Diagnosis of Knee Osteoarthritis: Enhancing Model Accuracy with CleanLab Relabeling

<b>Background:</b> Knee Osteoarthritis (KOA) is a prevalent and debilitating joint disorder that significantly impacts quality of life, particularly in aging populations. Accurate and consistent classification of KOA severity, typically using the Kellgren-Lawrence (KL) grading system, is crucial for effective diagnosis, treatment planning, and monitoring disease progression. However, traditional KL grading is known for its inherent subjectivity and inter-rater variability, which underscores the pressing need for objective, automated, and reliable classification methods. <b>Methods:</b> This study investigates the performance of an EfficientNetB5 deep learning model, enhanced with transfer learning from the ImageNet dataset, for the task of classifying KOA severity into five distinct KL grades (0-4). We utilized a publicly available Kaggle dataset comprising 9786 knee X-ray images. A key aspect of our methodology was a comprehensive data-centric preprocessing pipeline, which involved an initial phase of outlier removal to reduce noise, followed by systematic label correction using the Cleanlab framework to identify and rectify potential inconsistencies within the original dataset labels. <b>Results:</b> The final EfficientNetB5 model, trained on the preprocessed and Cleanlab-remediated data, achieved an overall accuracy of 82.07% on the test set. This performance represents a significant improvement over previously reported benchmarks for five-class KOA classification on this dataset, such as ResNet-101 which achieved 69% accuracy. The substantial enhancement in model performance is primarily attributed to Cleanlab's robust ability to detect and correct mislabeled instances, thereby improving the overall quality and reliability of the training data and enabling the model to better learn and capture complex radiographic patterns associated with KOA. Class-wise performance analysis indicated strong differentiation between healthy (KL Grade 0) and severe (KL Grade 4) cases. However, the "Doubtful" (KL Grade 1) class presented ongoing challenges, exhibiting lower recall and precision compared to other grades. When evaluated against other architectures like MobileNetV3 and Xception for multi-class tasks, our EfficientNetB5 demonstrated highly competitive results. <b>Conclusions:</b> The integration of an EfficientNetB5 model with a rigorous data-centric preprocessing approach, particularly Cleanlab-based label correction and outlier removal, provides a robust and significantly more accurate method for five-class KOA severity classification. While limitations in handling inherently ambiguous cases (such as KL Grade 1) and the small sample size for severe KOA warrant further investigation, this study demonstrates a promising pathway to enhance diagnostic precision. The developed pipeline shows considerable potential for future clinical applications, aiding in more objective and reliable KOA assessment.