The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging
The Dallas Lifespan Brain Study (DLBS) was designed to integrate brain and cognition across the adult lifespan. Participants (n = 464) were between age 21 and 89 years at time of first assessment and returned approximately every 3.5-5 years for a second (n = 338) and third epoch (n = 224) of data collection. The three epochs included a comprehensive neuropsychological battery, questionnaires that assessed physical health, psychosocial status, and brain health, structural MRI scans (including T1-weighted imaging and diffusion-weighted imaging), a hypercapnia scan, an arterial spin labeling scan, and four functional fMRI scans. Additionally, measures of amyloid and tau were collected with AV-45 (Florbetapir) and AV-1451 (Flortaucipir). Key innovations were robust sampling of middle-aged participants and inclusion of PET data for amyloid and tau in a cognitively normal sample. This large data set has recently been published on OpenNeuro.org open-access and provides the opportunity for researchers to test many hypotheses about brain and cognition across human adulthood, including longitudinal hypotheses, with these data across a multi-year span.
Authors
- Xiankai Sun (ORCID: https://orcid.org/0000-0002-5140-6110)
- Hanzhang Lu (ORCID: https://orcid.org/0000-0003-3871-1564)
- Peiying Liu (ORCID: https://orcid.org/0000-0003-0830-5960)
- Marianna Dakanali
- Xi Chen (ORCID: https://orcid.org/0000-0003-1998-8461)
- Gagan S. Wig (ORCID: https://orcid.org/0000-0002-6432-5192)
- Evan T. Smith (ORCID: https://orcid.org/0000-0002-5075-0649)
- Joseph P. Hennessee (ORCID: https://orcid.org/0000-0002-1189-0649)
- Kristen M. Kennedy (ORCID: https://orcid.org/0000-0001-5373-9026)
- Denise C. Park (ORCID: https://orcid.org/0000-0003-2050-3513)
- Micaela Y. Chan (ORCID: https://orcid.org/0000-0001-6854-3755)
- Karen M. Rodrigue (ORCID: https://orcid.org/0000-0002-4781-7961)
- Michelle E. Farrell
- William Moore
- C.A. Tamminga
- Neil Rofsky
Institutions
- University of Maryland, Baltimore (US)
- Harvard University (US)
- Johns Hopkins University (US)
- The University of Texas at Dallas (US)
- Johns Hopkins Medicine (US)
- Stony Brook School (US)
- Massachusetts General Hospital (US)
- Southwestern Medical Center (US)
- Stony Brook University (US)
- The University of Texas Southwestern Medical Center (US)
- University of North Texas at Dallas (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Scientific Data
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1038/s41597-025-04847-7
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Eli Lilly and Company
- National Institutes of Health
- Avid Radiopharmaceuticals
- National Institute on Aging