Evodiamine induces ferroptosis in prostate cancer cells by inhibiting TRIM26-mediated stabilization of GPX4
This study demonstrates that evodiamine exerts potent antitumor effects against prostate cancer through inhibiting TRIM26-mediated stabilization of GPX4 protein and triggering ferroptosis. These findings suggest that evodiamine, a natural product derived from traditional Chinese medicine, could be a promising therapeutic agent for prostate cancer.
Authors
- Shanhui Liu (ORCID: https://orcid.org/0000-0001-9254-5339)
- Shengjun Fu (ORCID: https://orcid.org/0009-0001-8619-8964)
- Tao Yan (ORCID: https://orcid.org/0000-0002-2464-2361)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4443-1403)
- Ke Wang (ORCID: https://orcid.org/0000-0002-6163-4512)
- Lanlan Li (ORCID: https://orcid.org/0000-0002-8284-4586)
- Wenyan Li (ORCID: https://orcid.org/0000-0002-4545-2604)
- Jianzhong Lu
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s13020-025-01130-0
- Citations
- 4
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Lanzhou University
- National Natural Science Foundation of China