IgG promotes TNF‐α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF‐κB signalling pathway
Our findings clarified that IgG aggravated TNF-α-mediated osteoclastogenesis, further elucidating the mechanistic basis for the divergent manifestations of joint bone damage in SLE and RA.
Authors
- Haifeng Yin (ORCID: https://orcid.org/0000-0001-7042-7630)
- Guo‐Min Deng (ORCID: https://orcid.org/0000-0001-7488-1304)
- Yao Teng
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/cti2.70034
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China