Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD® rats
Although pulmonary macrophage activity increased in mice following exposure to L-MWNT-1020, systemic immune function for the most part remained unaffected. In contrast, rats demonstrated a slight decrease in humoral immune function as well as an increase in spleen cell numbers, T cell, and NK cell populations suggesting species-specific effects on systemic immunity, however, these effects were small and their biological significance with respect to altering disease susceptibility is unclear.
Authors
- Michelle Cora (ORCID: https://orcid.org/0000-0002-4714-1324)
- Victor J. Johnson
- Nigel J. Walker (ORCID: https://orcid.org/0000-0002-9111-6855)
- Gregory L. Baker (ORCID: https://orcid.org/0000-0002-6910-3011)
- Dori R. Germolec (ORCID: https://orcid.org/0000-0003-4072-1956)
- Gary R. Burleson
- Barney Sparrow
- Michael I. Luster
Institutions
- Battelle (US)
- National Institute of Environmental Health Sciences (US)
- Sarepta Therapeutics (United States) (US)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/ftox.2025.1539810
- Citations
- 1
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- U.S. Department of Health and Human Services
- Battelle
- National Institutes of Health