Investigation into the Mechanisms of Paeoniae Radix Rubra in the Treatment of Venous Thrombosis Using Network Pharmacology, Bioinformatics, and Molecular Docking Techniques

Through this study, it was found that PRR may act on targets, such as MAPK1 and NFATC1, through components like beta-sitosterol and Stigmasterol. Among them, the complex (beta-sitosterol - MAPK1) may be the key active component that plays a role in treating VTE.

Authors

Jinhao Xue
Ajiao Hou (ORCID: https://orcid.org/0000-0002-4632-4313)
Shuo Xu (ORCID: https://orcid.org/0000-0003-1722-9023)
Yang Liu (ORCID: https://orcid.org/0000-0002-5414-7185)
Hai Jiang (ORCID: https://orcid.org/0000-0002-2722-3330)
Jiaxu Zhang (ORCID: https://orcid.org/0000-0002-2177-1889)
Shiwen Gao

Institutions

Heilongjiang University of Chinese Medicine (CN)

Publication Details

Journal: Current Pharmaceutical Design
Published: 2025-05-26
DOI: https://doi.org/10.2174/0113816128374345250521115849
Citations: 1
Primary Topic: Traditional Chinese Medicine Analysis
Type: article
Field-Weighted Citation Impact: 2.38

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article

Investigation into the Mechanisms of Paeoniae Radix Rubra in the Treatment of Venous Thrombosis Using Network Pharmacology, Bioinformatics, and Molecular Docking Techniques

Jinhao Xue, Ajiao Hou, Shuo Xu, Yang Liu et al.

May 26, 2025

1 citations

Current Pharmaceutical Design

Traditional Chinese Medicine Analysis

2.38

article

Investigation into the Mechanisms of Paeoniae Radix Rubra in the Treatment of Venous Thrombosis Using Network Pharmacology, Bioinformatics, and Molecular Docking Techniques

Jinhao Xue, Ajiao Hou, Shuo Xu, Yang Liu, Hai Jiang, Jiaxu Zhang, Shiwen Gao

May 26, 2025article en

1 citations

Abstract

Through this study, it was found that PRR may act on targets, such as MAPK1 and NFATC1, through components like beta-sitosterol and Stigmasterol. Among them, the complex (beta-sitosterol - MAPK1) may be the key active component that plays a role in treating VTE.

Current Pharmaceutical DesignVol. 31(38)

Heilongjiang University of Chinese Medicine (CN)

Affordable and clean energy

Openalex Percentile: Top 13%

Traditional Chinese Medicine Analysis

2.38

DOI Source OpenAlex

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