Interleukin‐1 Signaling on Vascular Smooth Muscle Cells Accelerates Atherosclerosis in a Murine Model of Kawasaki Disease
Our results suggest an important pathophysiologic link between IL-1 signaling on vascular smooth muscle cells and subsequent acceleration of atherosclerosis in hypercholesterolemic mice following KD vasculitis. Thus, further studies are warranted to investigate the role of IL-1 signaling not only in acute KD but also in the subsequent vascular remodeling and long-term complications of KD vasculitis, including accelerated atherosclerosis.
Authors
- Debbie Moreira (ORCID: https://orcid.org/0009-0004-0983-3313)
- Malcolm Lane
- Moshe Arditi (ORCID: https://orcid.org/0000-0001-9042-2909)
- Timothy R. Crother (ORCID: https://orcid.org/0000-0001-8465-6127)
- Aslı Yıldırım (ORCID: https://orcid.org/0000-0002-5654-3093)
- Magali Noval Rivas (ORCID: https://orcid.org/0000-0001-5570-8928)
- Asli E. Atici (ORCID: https://orcid.org/0000-0003-1546-7191)
- Emily Aubuchon
- Shuang Chen (ORCID: https://orcid.org/0000-0002-2919-4967)
- Youngho Lee (ORCID: https://orcid.org/0000-0002-5227-683X)
- Kenichi Shimada (ORCID: https://orcid.org/0000-0001-8213-5686)
- Alexander Hsu‐Wilbraham
Institutions
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1161/jaha.124.040687
- Citations
- 1
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 2.01