Merging Paired Electrolysis and Copper Catalysis Enables Electrochemical Arylation of Aziridine for the Synthesis of 1,2-Amino Tertiary Alcohols

1,2-Amino alcohols are omnipresent in bioactive molecules. Conventional approaches to this motif require multistep reactions. Herein, we develop an electrochemical strategy for copper-catalyzed convergent paired electrolysis. By selectively cleaving the C-N bond of 2-aryl-1-tosylaziridines with electron-deficient aromatics as the aryl source, the 1,2-amino tertiary alcohol scaffold is rapidly constructed. This method features mild reaction conditions, large-scale preparation, and a lack of sacrificial electrodes. Experimental studies and DFT calculations indicate that this reaction tends toward radical cross-coupling.