Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China
Dotinurad 4 mg/day was superior to febuxostat 40 mg/day in achieving serum urate levels ≤6.0 mg/dL at week 24 and was well tolerated in Chinese patients with gout.
Authors
- Yibing Lu
- Yongjing Cheng (ORCID: https://orcid.org/0000-0002-5453-7298)
- Dongzhou Liu
- Xiaodan Kong (ORCID: https://orcid.org/0000-0002-5255-4588)
- Yu Liu (ORCID: https://orcid.org/0000-0002-7968-0162)
- Zhenyu Jiang (ORCID: https://orcid.org/0000-0001-8497-3405)
- Zhuoli Zhang (ORCID: https://orcid.org/0000-0001-7219-9141)
- Motohisa Kawakatsu
- Shan Yu (ORCID: https://orcid.org/0000-0001-9740-0956)
- Bin Yi (ORCID: https://orcid.org/0000-0002-9239-8639)
- Zhengnan Gao (ORCID: https://orcid.org/0000-0002-0077-8758)
- Hongfeng Zhang (ORCID: https://orcid.org/0009-0001-3186-3357)
- Jiankang Hu
- Dongmei Guo (ORCID: https://orcid.org/0000-0002-7332-380X)
- Yu Wang (ORCID: https://orcid.org/0000-0003-4505-1816)
- Changgui Li (ORCID: https://orcid.org/0000-0002-4622-3731)
- Baijie Xu
- Kohei Ishikawa
- Jia Sun (ORCID: https://orcid.org/0009-0003-3234-2128)
- Rieko Kokan
Institutions
- Qingdao University (CN)
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Dalian Medical University (CN)
- Jilin University (CN)
- Peking University (CN)
- Renji Hospital (CN)
- People 's Hospital of Jilin Province (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- ShenZhen People’s Hospital (CN)
- First People's Hospital of Foshan (CN)
- Dalian Municipal Central Hospital (CN)
- Deyang Stomatological Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Beijing Hospital (CN)
- Zhujiang Hospital (CN)
- Jiangxi Pingxiang People's Hospital (CN)
- First Hospital of Jilin University (CN)
- Peking University First Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Third Xiangya Hospital (CN)
- Eisai (Japan) (JP)
- Southern Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1002/art.43261
- Citations
- 2
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Eisai