LRRFIP1 enhances the Wnt/β-catenin pathway by binding to DVLs in myelodysplastic syndrome
LRRFIP1 can promote the proliferation of MDS cells and inhibit apoptosis, and LRRFIP1 and Dvl can synergistically enhance the activity of the Wnt/β-catenin signaling pathway in MDS, thus providing evidence for LRRFIP1's involvement in the pathogenesis of MDS.
Authors
- Han Zhu (ORCID: https://orcid.org/0000-0002-6274-852X)
- Yutian Lei (ORCID: https://orcid.org/0000-0001-6552-7645)
- Jianyong Li (ORCID: https://orcid.org/0000-0003-2154-830X)
- Wenyi Shen (ORCID: https://orcid.org/0000-0001-8673-0407)
- Yu Zhu (ORCID: https://orcid.org/0000-0002-6928-4027)
- Sixuan Qian (ORCID: https://orcid.org/0000-0003-1049-4238)
- Xiaoli Zhao (ORCID: https://orcid.org/0009-0005-1916-9871)
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12967-025-06429-y
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China