Mechanism of Alcohol-Mediated CyPD Regulation in mPTP-Dependent Myocardial Injury

CyPD是构成mPTP的基本组成部分之一，且有一些明确的证据支持CyPD是mPTP的主要调节因子；CyPD仍是唯一被遗传学证明的mPTP开放因子；CyPD的表达增加能够经历多种翻译后修饰，如磷酸化、氧化、乙酰化和硝酰化调控mPTP的打开。mPTP的长期开放能够引起线粒体功能障碍，进而导致心肌损伤，目前已有研究表明酒精能够使线粒体上mPTP上CyPD的表达增加及CyPD mRNA表达增加，但酒精通过何种机制引起线粒体上CyPD的表达增加目前尚不清楚，本文就酒精可能通过哪些机制引起CyPD的表达发生变化做一综述。CyPD is one of the fundamental components of mPTP, and substantial evidence indicates that CyPD serves as the primary regulatory factor of mPTP. Moreover, CyPD remains the only genetically validated factor responsible for the opening of mPTP. Enhanced expression of CyPD undergoes various post-translational modifications, including phosphorylation, oxidation, acetylation, and nitroacylation, which collectively regulate the opening of mPTP. The sustained opening of mPTP can lead to mitochondrial dysfunction, thereby causing myocardial injury. Current research demonstrates that alcohol increases the expression of both CyPD and CyPD mRNA in mPTP on mitochondria; however, the precise mechanism underlying alcohol-induced upregulation of CyPD expression on mitochondria remains elusive. This review aims to explore the potential mechanisms by which alcohol may induce changes in CyPD expression.