Morpholine Anchored Fluorogenic Toolkit: Unveiled Disease Allied Protein Fibrillation in Lysosomal Compartment of Live‐Cell and <i>Drosophila</i> Models (Small 21/2025)
Neurodegenerative Diseases Protein aggregation is a hallmark of neurodegenerative diseases. Far-red emissive SC-4mor selectively detects protein aggregates in lysosomes of live cells and Drosophila models (neurodegenerative and non-neurodegenerative disease models). Ability of SC-4mor to cross the blood-brain barrier in mice model highlights its potential for investigating the pathogenesis and progression of protein aggregation-related diseases in the near future. More in article number 2404008, Monalisa Mishra, Apurba Lal Koner, and co-workers.
Authors
- Debapriya Bhattacharya (ORCID: https://orcid.org/0000-0003-2732-6599)
- Apurba Lal Koner (ORCID: https://orcid.org/0000-0002-8891-416X)
- P. Kavyashree
- Lopamudra Mishra (ORCID: https://orcid.org/0000-0003-3533-4740)
- Akshay Silswal (ORCID: https://orcid.org/0000-0003-4088-7913)
- Harry Wilson
- Monalisa Mishra
Institutions
- National Institute of Technology Rourkela (IN)
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Small
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/smll.202570164
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00