MICRO-RNA-S AS MEDIATORS IN DEVELOPMENT OF PSORIASIS

Psoriasis is a chronic inflammatory skin disease driven by complex epigenetic-immunological interactions. Although some immunological mechanisms have been characterized, the primary initiating factor of psoriasis remains elusive. The discovery of non-coding RNAs and their role as gene expression regulators has revealed their critical involvement in the pathogenesis of different diseases, including psoriasis. This paper examines the contribution of specific dysregulated miRNAs to psoriatic inflammation, focusing on the most upregulated or downregulated (miR-21, miR-31, miR-99a, miR-125b, miR-155, miR-203) species. We discuss how these miRNAs form pathogenic feed-forward loops, that amplify inflammation and sustain keratinocyte dysfunction, which are fundamental factors in psoriasis, The intricate crosstalk between these miRNAs and Th17-associated cytokines (IL-17, IL-23) further complicates the disease network. Finally, we highlight miRNAs as potential biomarkers and therapeutic targets in psoriasis management.