Acquired Hemophilia A Presenting as a Spontaneous Soft Tissue Hematoma in an Elderly Male
Acquired hemophilia A (AHA) is a rare but potentially life-threatening autoimmune bleeding disorder characterized by autoantibodies against factor VIII. It often presents with spontaneous bleeding in patients without a personal or family history of coagulopathy, making diagnosis particularly challenging. We present a case of a 60-year-old male with a remote history of right total hip arthroplasty (THA) who developed a spontaneous intra-articular hematoma, initially mistaken for a periprosthetic infection. He later re-presented with expanding ecchymosis and anemia, ultimately diagnosed with AHA following hematology evaluation. This case highlights the diagnostic pitfalls and emphasizes the importance of considering acquired coagulopathies in unexplained bleeding.
Authors
- John Adabie Appiah (ORCID: https://orcid.org/0000-0002-0386-6120)
- Karna Desai
- Hassham Bin Khalid
- Richeal Asante
- Chukwunonso B Ubanatu
Institutions
- Geisinger Health System (US)
Publication Details
- Journal
- Cureus
- Published
- 2025-05-26
- DOI
- https://doi.org/10.7759/cureus.84820
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00