Acquired Hemophilia A Presenting as a Spontaneous Soft Tissue Hematoma in an Elderly Male

Acquired hemophilia A (AHA) is a rare but potentially life-threatening autoimmune bleeding disorder characterized by autoantibodies against factor VIII. It often presents with spontaneous bleeding in patients without a personal or family history of coagulopathy, making diagnosis particularly challenging. We present a case of a 60-year-old male with a remote history of right total hip arthroplasty (THA) who developed a spontaneous intra-articular hematoma, initially mistaken for a periprosthetic infection. He later re-presented with expanding ecchymosis and anemia, ultimately diagnosed with AHA following hematology evaluation. This case highlights the diagnostic pitfalls and emphasizes the importance of considering acquired coagulopathies in unexplained bleeding.

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Publication Details

Journal
Cureus
Published
2025-05-26
DOI
https://doi.org/10.7759/cureus.84820
Primary Topic
Hemophilia Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Acquired Hemophilia A Presenting as a Spontaneous Soft Tissue Hematoma in an Elderly Male

John Adabie Appiah, Karna Desai, Hassham Bin Khalid, Richeal Asante et al.
Cureus
Hemophilia Treatment and Research
article

Acquired Hemophilia A Presenting as a Spontaneous Soft Tissue Hematoma in an Elderly Male

John Adabie Appiah, Karna Desai, Hassham Bin Khalid, Richeal Asante, Chukwunonso B Ubanatu
article en

Abstract

Acquired hemophilia A (AHA) is a rare but potentially life-threatening autoimmune bleeding disorder characterized by autoantibodies against factor VIII. It often presents with spontaneous bleeding in patients without a personal or family history of coagulopathy, making diagnosis particularly challenging. We present a case of a 60-year-old male with a remote history of right total hip arthroplasty (THA) who developed a spontaneous intra-articular hematoma, initially mistaken for a periprosthetic infection. He later re-presented with expanding ecchymosis and anemia, ultimately diagnosed with AHA following hematology evaluation. This case highlights the diagnostic pitfalls and emphasizes the importance of considering acquired coagulopathies in unexplained bleeding.

CureusVol. 17(5)
Geisinger Health System (US)
Gender equality
Openalex Percentile: Top 86%
Hemophilia Treatment and Research
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Acquired Hemophilia A Presenting as a Spontaneous Soft Tissue Hematoma in an Elderly Male — John Adabie Appiah, Karna Desai, et al. · Cureus (2025) | TGRS Research Map | TGRS