Blood Analysis of Patients with Rheumatoid Disease from Kosovo Using Non-Steroidal Anti Inflammatory Drug – Aspirin

Bone tissue, one of the body’s most intricate structures, has a unique capacity for spontaneous regeneration and repair under optimal physio logical conditions. Aspirin, a widely used non-steroidal anti-inflammatory drug (NSAID) recognized for its anticoagulant properties, plays a role in bone regeneration by activating cytokines and mediators within osteoclasts, osteoblasts, and progenitor cells at sites of damage. This ac tivation promotes bone repair and stimulates angiogenesis by enhancing endothelial cell migration, which is essential for the formation of new blood vessels necessary for fracture healing. This study analyzed blood samples from 100 Kosovo patients (57 female, 43 male; ages 42–89) with rheumatic osteoporosis who regularly use aspirin. Key biomarkers measured included vitamin D, serum calcium, serum iron, sedimentation rate, glucose, triglycerides, cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Findings indicated that 37% of these osteoporosis patients exhibited elevated triglyceride levels (>1.7 mmol/L), while nearly 40% had cholesterol levels exceeding 5 mmol/L. Additionally, AST and ALT levels were elevated (>40 IU/L) in 30% of patients, with aspirin users generally showing statistically significant increases across these blood parameters. Body mass index showed no statistically significant correlation with any blood parameter values. However, increasing patient age correlated with reduced vitamin D levels and elevated triglycerides, cholesterol, sedimentation rate, and glucose levels. Understanding the link between diet and osteoporosis is critical for healthcare professionals, including doctors, nutritionists, and researchers, as it supports efforts to prevent and manage osteoporosis.