Necrotizing Fasciitis: Obscure Nature and Challenging Diagnosis (Review)

Necrotizing fasciitis is a rapidly progressive synergistic aerobical-anaerobical deadly infection. It spreads quickly along the fascial planes leading to widespread soft tissue gangrene and systemic sepsis. Early diagnosis of the disease is critical to ensure timely and effective treatment, as delays significantly increase morbidity and mortality rates. Keeping high index of suspicion at initial presentation and raising clinical awereness are of paramount importance. Despite better knowledge and advancements in laboratory diagnostics, clinical judgment is still challenging and remains the cornerstone of early detection. This review discusses the key elements involved in the diagnostic evaluation of necrotizing fasciitis.