Miltefosine analogues with comparable antileishmanial activity and significantly reduced macrophage cytotoxicity
The MIL analogues TC387, TC388, and TC437 exhibited superior SI and comparable or slightly enhanced antileishmanial activity relative to MIL, along with very low hemolytic potential. These findings support further investigation of these analogues as promising oral therapeutic candidates for leishmaniasis.
Authors
- Theodora Calogeropoulou (ORCID: https://orcid.org/0000-0002-3369-5393)
- Miriam Leandro Dorta (ORCID: https://orcid.org/0000-0003-3563-9405)
- Antônio Alonso (ORCID: https://orcid.org/0000-0003-4768-6372)
- María Laura Bolognesi (ORCID: https://orcid.org/0000-0002-1289-5361)
- Rodrigo Saar Gomes (ORCID: https://orcid.org/0000-0001-9551-9419)
- Luiz Antônio Soares Romeiro (ORCID: https://orcid.org/0000-0001-5679-0820)
- George Ε. Magoulas (ORCID: https://orcid.org/0000-0001-8944-1635)
- Laís Flávia Nunes Lemes (ORCID: https://orcid.org/0000-0002-2904-5291)
- Brenda de Lucena Costa
- Laís Alonso
Institutions
- Universidade de Brasília (BR)
- Universidade Católica de Brasília (BR)
- National Hellenic Research Foundation (GR)
- Universidade Federal de Goiás (BR)
- University of Bologna (IT)
Publication Details
- Journal
- Memórias do Instituto Oswaldo Cruz
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/0074-02760240219
- Citations
- 5
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.39