Synthesis of β‐N‐Heterocyclic‐Cyclobutane‐Fused Bicyclic γ‐Lactones from 2‐Hydroxycyclobutanone and Carboxamide‐Bearing Wittig Reagents
A cascade reaction has been established that enables access to structurally diverse 2‐oxabicyclo[3.2.0]heptan‐3‐ones bearing a benzo[ d ]oxazol‐2(3H)‐one moiety at the bridgehead quaternary center in moderate to good yields in a single operation. The reaction illustrates the potential of 2‐hydroxycyclobutanone as a substrate for the rapid preparation of unusual and complex molecular frameworks.
Authors
- Angelo Frongia (ORCID: https://orcid.org/0000-0003-4652-9578)
- V. Frau
- David J. Aitken (ORCID: https://orcid.org/0000-0002-5164-6042)
- Stefano Barranco
- Régis Guillot (ORCID: https://orcid.org/0000-0002-9003-0670)
- Pierluigi Caboni (ORCID: https://orcid.org/0000-0003-2448-3767)
- Mauro Uras
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Cagliari (IT)
- Université Paris-Saclay (FR)
- Institut des Sciences des Plantes de Paris Saclay (FR)
- Institut des Sciences Moléculaires d'Orsay (FR)
- Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari (IT)
- Institut de Chimie Moléculaire et des Matériaux d'Orsay (FR)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1002/ejoc.202500332
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00