The association between the uric acid-to-high-density lipoprotein cholesterol ratio and osteoarthritis risk in U.S. adults: a cross-sectional study based on NHANES 1999–2016
This study revealed a nonlinear relationship between the UHR and OA, with a threshold at UHR = 0.109. Below this level, the UHR was significantly negatively associated with OA, especially in older adults (≥ 50 years old), females, drinkers, non-Hispanic Whites, and those with an education level above high school, or no metabolic diseases.
Authors
- Fangjun Xiao (ORCID: https://orcid.org/0000-0002-3945-5526)
- Y. Ao (ORCID: https://orcid.org/0009-0005-1187-1607)
- Jiangfeng Lyu
- Junpeng Qiu (ORCID: https://orcid.org/0009-0001-6736-3389)
- Wei Luo (ORCID: https://orcid.org/0000-0001-6951-7698)
- Yang Junxing
- Yifei Liufu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12944-025-02618-2
- Citations
- 3
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 4.29