Anti‐Ro52/TRIM21 autoantibodies predict Sjögren's syndrome in patients with primary biliary cholangitis
We observed a 16.9% positivity of anti-Ro52 autoantibodies and an association between having these autoantibodies and elevated IgG, the symptom dry mouth, and having Sjögren's syndrome. Furthermore, we found a sizable undiagnosed group of Sjögren's patients in the anti-Ro52 positive subgroup. Our results suggest that Sjögren's patients are underdiagnosed in patients with PBC. We propose that patients with PBC be tested for anti-Ro52 autoantibodies and, if positive, referred for rheumatological examination.
Authors
- Marie Louise Næstholt Dahl (ORCID: https://orcid.org/0000-0003-2138-2477)
- Bent Deleuran (ORCID: https://orcid.org/0000-0002-7079-1587)
- Christian Brix Folsted Andersen (ORCID: https://orcid.org/0000-0001-6182-2436)
- Malene Hvid (ORCID: https://orcid.org/0000-0002-3602-4261)
- Jakob Hauge Mikkelsen (ORCID: https://orcid.org/0000-0002-2914-3297)
- Peter Holland‐Fischer (ORCID: https://orcid.org/0000-0002-6082-3338)
- Trine‐Line Korsholm (ORCID: https://orcid.org/0000-0001-7132-5978)
- Henning Grønbæk (ORCID: https://orcid.org/0000-0001-8998-7910)
- Jesper Bach Hansen
- Matias Hauge Böttcher (ORCID: https://orcid.org/0009-0005-3793-0935)
- Ayad Babaee (ORCID: https://orcid.org/0009-0002-7540-5742)
Institutions
- Aarhus University (DK)
- Aalborg University Hospital (DK)
- Aarhus University Hospital (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1111/hepr.14213
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gigtforeningen
- Grosserer L. F. Foghts Fond