Possibilities of improving the efficacy and safety of etiopathogenetic therapy of acute sinusitis

Introduction . Acute inflammatory diseases of the paranasal sinuses (PNS) have a high frequency, risks of transition to chronic forms and occurrence of various complications. Aim . To increase the effectiveness of complex therapy of acute sinusitis by influencing the etiopathogenetic mechanisms of the disease with a herbal medicinal product Sinupret extract. Materials and methods . 72 patients aged 19 to 54 years participated in the study, including males (n = 42) and females (n = 30), with a diagnosis of acute sinusitis (J01). The patients were randomly divided into two groups. Patients of the 1st main group (n = 37), in addition to the standard treatment, received a herbal medicinal product with pronounced anti-inflammatory and secretolytic effects for 7 days, and persons of the 2nd control group (n = 35) received treatment according to the latest clinical recommendations. According to the SF-36 questionnaire, the coefficient of poor quality of life of patients was determined. The clinical condition of the patients was assessed on the on the 3rd, 5th and 7th day after the start of treatment. Results and discussion . A decrease in the severity of subjective and objective symptoms of acute sinusitis during treatment was observed in both groups, but in patients of the main group who additionally took a multicomponent phytoniringovy drug, they were achieved faster, starting from 3rd day of therapy. By the end of treatment (7th day), nasal breathing improved significantly and amounted to 95.8% in the 1st group patients, while in the 2nd group patients this indicator was only 67%. Similar indicators were noted earlier for postnasal congestion, dysosmia, cephalgia, rhinorrhea, and restoration of mucociliary clearance. Conclusions . The use of a multicomponent phytonoring drug in the complex therapy of acute sinusitis at an earlier stage reduces the severity of clinical symptoms and inflammatory manifestations, is well tolerated by patients, and accelerates recovery time.