Improvement of topical therapy of acute nasopharyngitis in conditions of antibiotic resistance

Introduction . The issue of timely diagnosis, treatment and prevention of acute respiratory viral infections (ARVI) and their complications is relevant. Aim . Тo evaluate the effectiveness of treatment of acute nasopharyngitis with the inclusion of a drug with the active substance silver proteinate in complex therapy. Materials and methods . The study was conducted with the participation of 67 children of the younger age group of 7–10 years, including girls (n = 33) and boys (n = 34), with a verified diagnosis of acute nasopharyngitis (runny nose), J-00, who were divided into two groups. In addition to the standard treatment, children in the main group (n = 35) received a drug with antimicrobial and anti-inflammatory effects with an active substance in silver proteinate for 7 days, and children in the control group (n = 32) received standard treatment for acute nasopharyngitis, according to clinical recommendations. The complaints raised the coefficient of poor living conditions for patients, according to the results of the PSOM-31 questionnaire. The control points were on the 5 th and 7 th day after the start of treatment. Results and discussion . In patients of both groups, there was a decrease in the severity of subjective and objective symptoms of the disease, and to a greater extent in children who additionally took the drug with silver proteinate content. The best indicators of relief of nasopharyngeal symptoms by the 7 th day of treatment were recorded in individuals of the first group: a decrease in rhinorrhea by 26% and postnasal congestion by 65.5%. On day 7, the “general symptoms” worried the patients of the second group to a greater extent than those of the first group and were equal to 7.4 and 14.9 points according to the results of the PSOM-31 questionnaire, respectively. Patients of both groups receiving conservative therapy did not register any manifestations of allergies and side effects. Conclusion . The topical use of silver proteinate in the complex therapy of acute nasopharyngitis reduces local inflammatory manifestations in the nasopharynx, promotes an earlier recovery period, and is well tolerated by patients.