Seawater with silver ions in the elimination therapy of polypous sinusitis

Introduction . The main mechanism of the pathological process in polypous rhinosinusitis involves mucous membrane remodelling due to alterations followed by the formation of polypous vegetations that are likely to relapse. Aim . To conduct a clinical evaluation of the efficacy of the use of seawater spray with silver ions as part of the elimination therapy of polypous sinusitis. Materials and methods . We conducted a prospective randomized clinical trial involving 66 patients aged 20 to 46 years on an outpatient basis. The inclusion criterion included a diagnosis of chronic polypous rhinosinusitis in the exacerbation phase with attachment of a bacterial infection. All patients were randomly divided into 2 groups. The efficacy and safety of the use of seawater spray with silver ions was assessed on Days 3, 5 and 7 of treatment in Group 1 (n = 32) as compared to Group 2 (n = 34) which used the standard seawater spay. Results and discussion . On Day 7, the nasal breathing improved in 96.5% of patients in Group 1 and in 45% of patients in Group 2. 97.5% of patients in Group 1 reported the absence of nasal discharge on Day 7 as compare with 56.5% of patients in Group 2. The absence of postnasal drip was noted on Day 7 of therapy in 98.5% of patients in Group 1 and in 2.5% of patients in Group 2, respectively. The SF-36 QoL trend scores showed a more significant improvement of the patients’ health status on Day 7 of the therapy from 89.4 to 98.9 scores and from 84.6 to 91.1 points in patients of Groups 1 and 2, respectively. Conclusions . The clinical assessment of the efficacy of the use of seawater spray with silver ions as part of the elimination therapy of polypous sinusitis discovered a significant reduction in clinical symptoms.