Micro- and nanoplastics reduce the phagocytosis and intracellular killing of E. coli by THP1-Blue™ NFκB monocytes
Exposure to micro- and nanoplastic reduced the ability of phagocytes to internalize and kill bacteria. High plastic concentrations decreased the endotoxin-stimulated phagocytosis of bacteria. Hence, exposure to plastic particles may reduce the host`s immune defence against bacterial pathogens.
Authors
- Roland Nau (ORCID: https://orcid.org/0000-0001-8316-995X)
- H. Ludwig (ORCID: https://orcid.org/0000-0001-8744-9510)
- Jana Seele (ORCID: https://orcid.org/0000-0002-2452-965X)
- Michael J. Moritz (ORCID: https://orcid.org/0000-0002-6482-3546)
- Florian Edbauer
Institutions
- Universitätsmedizin Göttingen (DE)
- Evangelisches Krankenhaus Göttingen-Weende (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Infection
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1007/s15010-025-02565-1
- Citations
- 3
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 1.51
Funders
- Georg-August-Universität Göttingen