Expression of LHCG receptor in the mouse vulva

The elevated serum LHCG concentrations have been detected between 40 and 70 years both in male and female. In previous studies LHCG receptor was detected in the mouse and human penis both in corpus cavernosum penis and corpus spongiosum penis. There is no information about the expression of LHCG receptor in the vulva up to now. The aim of present study is to investigate the expression of the LHCG receptor in the mouse vulva tissue to see, if the LH effects can be possible in vulva. 12 Balb/c mice (7–8 weeks old) were used as donors of normal vulva tissue. Immunohistochemistry was used for the detection of the LHCG receptor. Positive immunoreaction for LHCG receptors was detected in the epithelial cells in all layers of the mouse vulva epithelium, in the epithelial cells of the gland ducts and in the interstitial cells of subepithelial connective tissue. The high postmenopausal gonadotrophin concentrations could have direct effects on the vulvar tissue, if there are receptors for them. LHCG receptors were detected in the different cell types in the mouse vulva. It could be possible that the higher serum LH concentrations both in aging male and female could have direct effects on the spongious tissue both in the individual and his/her partner. Further studies are indicated.