The mechanism of liraglutide on promoting osteogenesis via macrophages polarization under the inflammatory and oxidative stress in osteoporosis
Lira inhibits inflammation and oxidation through decreasing TNF-α pathway of macrophage and Nrf2 translocation of MC3T3-E1, that results in osteogenesis and anti-apoptosis in OP.
Authors
- Hui Dong (ORCID: https://orcid.org/0000-0002-0563-3662)
- Qiangbo Tan
- Zelin Wang (ORCID: https://orcid.org/0000-0003-3242-4150)
- Yaran Zang
- Huiying Liu (ORCID: https://orcid.org/0000-0002-9088-8247)
- Zhaoqiang Zhang (ORCID: https://orcid.org/0000-0002-9183-7273)
- Yue Hu (ORCID: https://orcid.org/0000-0001-5634-6674)
- Yuzhu He (ORCID: https://orcid.org/0000-0003-1137-2259)
- Wenqi Fu (ORCID: https://orcid.org/0000-0002-4847-9191)
- Shuangli Zhu (ORCID: https://orcid.org/0009-0003-1379-0259)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.lfs.2025.123717
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province
- Key Scientific Research Project of Colleges and Universities in Henan Province