Using DeepLabCut-Live to probe state dependent neural circuits of behavior with closed-loop optogenetic stimulation
Integrating DeepLabCut-Live with optogenetics provides a powerful tool for dissecting the context-dependent role of sensory feedback and spinal interneurons in locomotion. This technique opens new avenues for uncovering the neural substrates of state-dependent behaviors and has broad applicability for studies of real-time closed-loop manipulation based on pose estimation.
Authors
- Victoria E. Abraira (ORCID: https://orcid.org/0000-0001-9936-9921)
- Joshua K. Thackray (ORCID: https://orcid.org/0000-0003-2828-452X)
- Mark A. Gradwell (ORCID: https://orcid.org/0000-0003-3308-8005)
- Melissa Gonzalez
- Kanaksha K. Temkar
- Komal Patel
Institutions
- Rutgers, The State University of New Jersey (US)
Publication Details
- Journal
- Journal of Neuroscience Methods
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.jneumeth.2025.110495
- Citations
- 3
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Pew Charitable Trusts
- Whitehall Foundation
- Craig H. Neilsen Foundation
- New Jersey Commission on Spinal Cord Research
- National Institute of Neurological Disorders and Stroke