Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance

TIMP4 overexpression exerts a protective effect in HF by inhibiting myocardial injury, inflammation, and apoptosis, and by regulating immune cell balance. These findings imply that targeting TIMP4 could potentially serve as a therapeutic strategy for HF, as it has the ability to regulate immune responses and minimize damage to the myocardium.

Authors

Wenting Lin (ORCID: https://orcid.org/0000-0002-1374-3087)
Chunfeng Li (ORCID: https://orcid.org/0000-0002-0601-4572)
Hongjie Li (ORCID: https://orcid.org/0000-0002-9364-9081)
Dapeng Wu (ORCID: https://orcid.org/0000-0001-9446-8365)
Lei Yu (ORCID: https://orcid.org/0000-0002-0237-8758)

Institutions

Qiqihar Medical University (CN)

Publication Details

Journal: Cardiology
Published: 2025-05-26
DOI: https://doi.org/10.1159/000545905
Citations: 1
Primary Topic: Atherosclerosis and Cardiovascular Diseases
Type: article
Field-Weighted Citation Impact: 0.80

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article

Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance

Wenting Lin, Chunfeng Li, Hongjie Li, Dapeng Wu et al.

May 26, 2025

1 citations

Cardiology

Atherosclerosis and Cardiovascular Diseases

0.80

article

Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance

Wenting Lin, Chunfeng Li, Hongjie Li, Dapeng Wu, Lei Yu

May 26, 2025article en

1 citations

Abstract

TIMP4 overexpression exerts a protective effect in HF by inhibiting myocardial injury, inflammation, and apoptosis, and by regulating immune cell balance. These findings imply that targeting TIMP4 could potentially serve as a therapeutic strategy for HF, as it has the ability to regulate immune responses and minimize damage to the myocardium.

Cardiology

Qiqihar Medical University (CN)

Good health and well-being

Openalex Percentile: Top 28%

Atherosclerosis and Cardiovascular Diseases

0.80

DOI Source OpenAlex

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Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance — Wenting Lin, Chunfeng Li, et al. · Cardiology (2025) | TGRS Research Map | TGRS