Extensive Bone Marrow Involvement by BRAF<sup>V660E</sup>-Mutated Bi-Phenotypic Erdheim-Chester Neoplasm/Rosai-Dorfman Disease (Mixed Histiocytic Neoplasm) with Atypical Histological Features and Fulminant Hemophagocytosis
The case highlights the need to recognize that ECD diagnosis requires integrating histopathology with clinical and radiographic findings. It emphasizes the importance of awareness of mixed histiocytosis features and the role of detecting BRAF mutations, even through immunohistochemistry, in suspected histiocytic neoplasms. Extensive bone marrow involvement by ECD is rarely described. To our knowledge, there are no prior reports of bi-phenotypic (concurrent) ECD/RDD mixed histiocytosis affecting the bone marrow.
Authors
- Aliya H Sange
- Awni Alshurafa (ORCID: https://orcid.org/0000-0002-4454-5307)
- Hasan Rizvi (ORCID: https://orcid.org/0000-0001-9013-0324)
- Ruba Yasin
- Zsolt Lengyel
- Mahir Petkar (ORCID: https://orcid.org/0000-0002-0297-8075)
- Dina Sameh Soliman (ORCID: https://orcid.org/0000-0002-0624-3973)
- Firyal Ibrahim
Institutions
- Cairo University (EG)
- National Center for Cancer Care and Research (QA)
- Weill Cornell Medical College in Qatar (QA)
- Dubai Medical College (AE)
- Hamad Medical Corporation (QA)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1159/000545775
- Primary Topic
- Histiocytic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hamad Medical Corporation
- Qatar National Library