Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway
Gastrodin enhances the Wingless (Wnt)/β-catenin signaling pathway by increasing β-catenin accumulation and nuclear migration as well as decreasing GSK-3β, which increases Runx2 expression, consequently encouraging MC3T3-E1 cell osteogenic differentiation, and may be applied as a potential drug for osteoporosis therapy and prevention.
Authors
- Cailiang Shen (ORCID: https://orcid.org/0000-0002-9835-6384)
- Zuomeng Wu
- Wei Jiang (ORCID: https://orcid.org/0000-0003-0596-7811)
- Jiaqi Wang (ORCID: https://orcid.org/0000-0002-3067-9187)
- Lifeng Zhang (ORCID: https://orcid.org/0000-0003-2236-9936)
- Wenshan Shan
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Molecular and Cellular Probes
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.mcp.2025.102035
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61