Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis
Collectively, these data demonstrate that loss of adipose-derived Ism1 disrupts lipid homeostasis and accelerates the development of hepatic steatosis. This study provides a genetic basis for Ism1's involvement in metabolic regulation, suggesting a potential therapeutic target for treating metabolic disorders.
Authors
- Jameel Lone (ORCID: https://orcid.org/0000-0003-4571-1335)
- Taylor G. Brown (ORCID: https://orcid.org/0000-0001-9817-2094)
- Katrin J. Svensson (ORCID: https://orcid.org/0000-0001-5376-5128)
- Veronica L. Li (ORCID: https://orcid.org/0000-0001-8888-3853)
- Laetitia Coassolo (ORCID: https://orcid.org/0000-0003-2138-4819)
- Saranya Chidambaranathan Reghupaty (ORCID: https://orcid.org/0000-0001-6660-1296)
- Rajagopalan Narasimhan
- Anup Patel (ORCID: https://orcid.org/0000-0003-0290-4719)
- Zewen Jiang (ORCID: https://orcid.org/0000-0002-3852-8666)
- Meng Zhao (ORCID: https://orcid.org/0000-0002-5415-8335)
- Ewa Bielczyk-Maczyńska (ORCID: https://orcid.org/0000-0002-0558-1188)
- Niels Banhos Danneskiold-Samsoee
Institutions
- Cardiovascular Institute of the South (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.molmet.2025.102172
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- American Heart Association
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases