Suppressing lipid biosynthesis in Mycobacterium tuberculosis through polyketide synthase 13 thioesterase inhibition: Insights from computational analysis
The study underlines the possibility of ZINC000008214766 acting as a potential lead compound in inhibiting Pks13-TE and presents a new therapeutic strategy against TB. These results also highlight the use of a computational workflow in drug discovery and give cause for belief that natural compounds can win the battle against resistant TB. Further in vitro and in vivo studies are warranted to validate these findings.
Authors
- Ibrahim Alzahrani (ORCID: https://orcid.org/0000-0003-3879-5833)
- Maha Alawi (ORCID: https://orcid.org/0000-0002-2114-2329)
- Vivek Dhar Dwivedi (ORCID: https://orcid.org/0000-0003-0767-1328)
- Mohammed H. Alruhaili (ORCID: https://orcid.org/0000-0001-8114-7212)
- Esam I. Azhar (ORCID: https://orcid.org/0000-0002-1736-181X)
- Hattan S. Gattan (ORCID: https://orcid.org/0000-0003-3514-4912)
- Azzah Alharbi (ORCID: https://orcid.org/0000-0002-6482-2762)
- Saad B Al Masaud
Institutions
- King Abdulaziz University (SA)
- King Abdulaziz Medical City (SA)
- Saveetha University (IN)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.jiph.2025.102835
- Citations
- 2
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61