No Genetic Causal Relationship between COVID-19 and Herpes Zoster: A Bidirectional Mendelian Randomization Analysis
Our findings provide no evidence of a causal relationship between genetic predisposition to COVID-19 and the risk of HZ reactivation. The observed clinical association may be attributable to non-genetic factors, such as immune suppression or stress related to COVID-19 and its treatment. Further studies are warranted to explore these alternative mechanisms and improve clinical management of HZ in the context of COVID-19.
Authors
- Jun Li (ORCID: https://orcid.org/0000-0001-7218-429X)
- Yumin Zheng (ORCID: https://orcid.org/0000-0002-6842-8252)
- Xinhua Hu (ORCID: https://orcid.org/0000-0003-3559-4024)
- Yuan Cao
Institutions
- University of Electronic Science and Technology of China (CN)
- Ruijin Hospital (CN)
- Fourth People's Hospital of Sichuan Province (CN)
Publication Details
- Journal
- Journal of Multidisciplinary Healthcare
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jmdh.s518008
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China