Ex vivo lung perfusion-to-lung transplant rat survival model with reproducible development of acute lung injury and graft rejection
Our F344-to-WKy EVLP-to-LTx model generates reproducible and clinically relevant histological, radiological, and immunological results similar to those seen in humans. The model is therefore well suited to experimental EVLP studies with long-term follow-up prior to moving to large animal and human studies.
Authors
- Ei Miyamoto (ORCID: https://orcid.org/0000-0002-9824-8957)
- Tereza Martinu (ORCID: https://orcid.org/0000-0001-9234-6807)
- S. Juvet (ORCID: https://orcid.org/0000-0002-7243-556X)
- Akihiro Ohsumi (ORCID: https://orcid.org/0000-0002-2847-9653)
- K. Boonstra (ORCID: https://orcid.org/0000-0002-6337-4419)
- Shaf Keshavjee (ORCID: https://orcid.org/0000-0003-4547-8094)
- Marcelo Cypel (ORCID: https://orcid.org/0000-0001-5652-1938)
- David Hwang (ORCID: https://orcid.org/0000-0003-0831-6053)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Sunnybrook Hospital (CA)
Publication Details
- Journal
- JHLT Open
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.jhlto.2025.100299
- Citations
- 1
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- United Therapeutics Corporation
- Cell Science Research Foundation
- Kyoto University Foundation
- Cystic Fibrosis Canada