In situ phenotypic and karyotypic co-detection of aneuploid TCs and TECs in cytological specimens with abnormal cervical screening results
The quantity of CD31<sup>-</sup> aneuploid TCs was associated with the severity of cervical lesions. In HPV16/18 positive patients, aneuploid CD31<sup>-</sup> TCs were significantly increased in the LSIL. Moreover, aneuploid CD31<sup>-</sup> TCs exhibited remarkable specificity for detecting HSIL<sup>+</sup>. Further studies are required to expand the potential clinical utility of detecting CD31<sup>-</sup> aneuploid TCs.
Authors
- Daisy Dandan Wang
- Xuexin Zhou
- Peter Ping Lin (ORCID: https://orcid.org/0000-0002-6869-9490)
- Yanling Wang (ORCID: https://orcid.org/0000-0002-7191-6660)
- Yongbin Yang (ORCID: https://orcid.org/0000-0003-0238-0230)
- Yaping Zhu
- Alexander Y. Lin (ORCID: https://orcid.org/0000-0003-4599-7230)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
- Cytel (United States) (US)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12885-025-14346-y
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00