Enhancing polarization contrast with depolarization mechanism using PS-OCT

The most direct way to improve the efficiency and accuracy of tissue identification is to enhance the image contrast of multiple polarization parameters at the same time. Unlike the widely used enhancement method of single parameter, the expressions of non-depolarizing parameters are combined considering the depolarization mechanism. These derived parameters are then applied to imaging ex-vivo mouse skin through PS-OCT system, which breaks through the limitations of high surface brightness and blurred deep tissue boundaries. The experimental results reveal spots, layers and boundaries patterns that are imperceptible in intensity image of OCT or conventional PS-OCT systems, suggesting a layer-like tissue organization, consistent with the morphology of skin tissues. The proposed parameters as the contrast mechanisms merit further exploration for applications in the diagnosis of human skin diseases.