Routing immunomodulatory cytokine-encoded mRNAs to the omentum: turning an enemy into an ally in peritoneal metastasis
Peritoneal metastases remain a significant clinical challenge owing to the immunosuppressive nature of the omentum, which serves as a protective niche for disseminated tumor cells. Our recent study explored the targeted delivery of immunomodulatory cytokine-encoded mRNAs to the omentum, aiming to shift its role from a tumor-supportive site to an immune-activating ally. Our findings highlight the potential of cytokine mRNA delivery as a novel and safe immunotherapeutic strategy for peritoneal metastases.
Authors
- Leire Arrizabalaga (ORCID: https://orcid.org/0000-0003-0423-8350)
- Ignacio Melero (ORCID: https://orcid.org/0000-0002-1360-348X)
- Pedro Berraondo (ORCID: https://orcid.org/0000-0001-7410-1865)
- Fernando Aranda (ORCID: https://orcid.org/0000-0002-9364-474X)
Institutions
- University of Oxford (GB)
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- OncoImmunology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1080/2162402x.2025.2510998
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gobierno de Navarra
- European Research Council
- Instituto de Salud Carlos III