CARDIAC MUSCLE MODELING DURING TREATMENT WITH ALISKIREN IN PATIENTS WITH HEART FAILURE

Background and objectives. The aim of the study was to study the cardiac muscle modeling during treatment with aliskiren in patients with heart failure (HF). Methods. To assess the treatment effects of aliskiren (follow-up period – 6 months) 60 randomly were selected patients with chronic HF of different classes. They were randomly assigned to the study groups. 55 patients treated with aliskiren (150 mg), and finished the study. Results. Significant changes have not observed for almost all echocardiographic parameters. Percentage of the patients with mitral valve regurgitations of 3rd and 4th grades were significantly decreased; percentages of the patients with tricuspid valve regurgitations of 2nd and 3rd grades were also decreased significantly. Conclusion. Based on the evaluation of the effects of 6-month treatment of the HF patients with Aliskiren, it may be concluded that Aliskiren showed better results in terms of reducing valvular regurgitations rather than improvement of echocardiographic parameters. To obtain more strong evidences, it is necessary to continue the study to provide the evidence-based results and conclusions.