Interaction of neuropilin-1 and hepatocyte growth factor/C-Met pathway in liver fibrosis progression in hepatocyte-specific NRP-1 knockout mice
HGF-induced upregulation of hepatocyte NRP-1, mediated by RARA binding to its promoter, drives liver fibrosis through c-Met pathway activation, highlighting NRP-1 as a potential therapeutic target for liver fibrosis.
Authors
- Huanran Lv
- Qiang Zhu (ORCID: https://orcid.org/0000-0002-5843-9724)
- Miaomiao Tian (ORCID: https://orcid.org/0000-0001-7187-1901)
- Jianni Qi (ORCID: https://orcid.org/0000-0002-9512-7762)
- Yuchan Xue
- Yanning Sun
- Minghao Sui
- Le Wang (ORCID: https://orcid.org/0000-0002-5023-1240)
- Xinyu Wang (ORCID: https://orcid.org/0000-0001-5377-0816)
- Miao Zhang (ORCID: https://orcid.org/0000-0002-4242-005X)
- Han Ding
- Xin Wang (ORCID: https://orcid.org/0000-0003-0880-0419)
- Shujun Ma
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1007/s00535-025-02262-8
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province