Associations of VEGF-D levels with clinical manifestations in lymphangioleiomyomatosis: a cross-sectional analysis of 631 cases
The findings highlighted the pivotal role of serum VEGF-D in LAM pathophysiology and underscore that age, TSC, retroperitoneal LAM, chylous effusion, AMLs, and high HRCT grade were independent risk factors for increased VEGF-D levels. VEGF-D is a valuable biomarker in evaluation of LAM and improve the efficiency of diagnostic algorithm.
Authors
- Luning Yang (ORCID: https://orcid.org/0000-0001-9056-5950)
- Kai‐Feng Xu (ORCID: https://orcid.org/0000-0002-7662-531X)
- Miaoyan Zhang
- Shao‐Ting Wang (ORCID: https://orcid.org/0000-0001-9976-0445)
- Junya Liu (ORCID: https://orcid.org/0000-0001-6651-2509)
- Xinlun Tian (ORCID: https://orcid.org/0000-0003-4307-6665)
- Chongsheng Cheng
- Xiaoxin Zhang (ORCID: https://orcid.org/0000-0002-7759-7402)
- Shuzhen Meng
- Wenshuai Xu (ORCID: https://orcid.org/0000-0002-3583-0851)
- Yani Wang (ORCID: https://orcid.org/0000-0001-9716-0710)
- Hanghang Wang (ORCID: https://orcid.org/0000-0002-0360-7428)
- Tengyue Zhang (ORCID: https://orcid.org/0000-0002-4055-3326)
- Jinrong Dai
- Yanli Yang (ORCID: https://orcid.org/0000-0002-5847-7632)
- Song Liu
- Danjing Hu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s13023-025-03802-4
- Citations
- 3
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- National Key Research and Development Program of China