Comparison of outcomes between haploidentical and matched related donors for <scp>chronic myelomonocytic leukemia</scp>: A multicenter real‐world study

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative strategy for patients with chronic myelomonocytic leukemia (CMML). However, few reports have investigated the outcomes of patients receiving haploidentical HSCT. To this end, we included 117 patients with haploidentical donors (HID) and 75 patients with matched related donors (MRD) from 28 centers across China to explore the prognostic impact of different transplantation modalities. We found no significant difference between these two groups in terms of event-free survival (EFS, p = .211), overall survival (OS, p = .503), cumulative incidence of relapse (CIR, p = .076) or non-relapse mortality (NRM, p = .794). The predominance of peripheral blood (PB) graft source over bone marrow and PB since 2020 may have contributed to the worse outcomes in the MRD group. Moreover, CMML-specific prognostic scoring system (CPSS) lower-risk patients benefited more from the HID modality with superior EFS (p = .006). Multivariate analysis indicated that advanced age (p = .013), anemia at diagnosis (p = .010), and donor relationship (parent-to-child, p = .013) were independently associated with worse EFS in the HID group. Our data suggested that HID was comparable to MRD in CMML. However, under certain conditions, such as CPSS lower-risk ones, HID was preferred.

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Publication Details

Journal
International Journal of Cancer
Published
2025-05-26
DOI
https://doi.org/10.1002/ijc.35485
Citations
3
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
5.31

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article

Comparison of outcomes between haploidentical and matched related donors for chronic myelomonocytic leukemia: A multicenter real‐world study

Yu Cai, Jia Feng, Kehong Bi, Hai Yi et al.
3 citations
International Journal of Cancer
Acute Myeloid Leukemia Research
5.31
article

Comparison of outcomes between haploidentical and matched related donors for chronic myelomonocytic leukemia: A multicenter real‐world study

Yu Cai, Jia Feng, Kehong Bi, Hai Yi, Yi Luo, Qian Cheng, Jing‐Zhi Wang, Xiang‐Yu Zhao, Xiao‐Jun Huang, Shun‐Qing Wang, Xianmin Song, Han Zhu, Feng‐Rong Wang, Yimei Feng, Xiao‐Dong Mo, Jianying Zhou, Yue Liu, Fang Zhou, Xin Du, Jianmin Yang, Ming Zhou, Yuhong Zhou, Xiang‐Li Chen, Kai‐Yan Liu, Ting Niu, Bao‐Dong Ye, Xi Yang, Ying‐Jun Chang, Zhilei Bian, Sujun Gao, Yi Chen, Yuanyuan Zhang, Xin Li, Qian Wang, Wen Wang, Fankai Meng, Hongyu Zhang, Li Liu, Xi Zhang, Shiyu Wang, Wei Han, Yuhong Chen, Ling Wei, Xiaohui Zhang, Zhidong Wang, Ya‐Jing Xu, Xue‐Qian Yan, Jie Ji, Ning Huang, Yu Wang, Ming Jiang, Hailong Yuan, Yuhua Li, Xiaobing Huang, Yuqian Sun, Yujun Dong, Lan‐Ping Xu, Libing Wang, Dingming Wan, Xiao‐Liang Liu, Lu‐Xin Yang, Rui Huang, Zunmin Zhu, Lixin Wu, Chenglu Yuan, Xudong Wei, Huan Chen, Yicheng Zhang
article en
3 citations

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative strategy for patients with chronic myelomonocytic leukemia (CMML). However, few reports have investigated the outcomes of patients receiving haploidentical HSCT. To this end, we included 117 patients with haploidentical donors (HID) and 75 patients with matched related donors (MRD) from 28 centers across China to explore the prognostic impact of different transplantation modalities. We found no significant difference between these two groups in terms of event-free survival (EFS, p = .211), overall survival (OS, p = .503), cumulative incidence of relapse (CIR, p = .076) or non-relapse mortality (NRM, p = .794). The predominance of peripheral blood (PB) graft source over bone marrow and PB since 2020 may have contributed to the worse outcomes in the MRD group. Moreover, CMML-specific prognostic scoring system (CPSS) lower-risk patients benefited more from the HID modality with superior EFS (p = .006). Multivariate analysis indicated that advanced age (p = .013), anemia at diagnosis (p = .010), and donor relationship (parent-to-child, p = .013) were independently associated with worse EFS in the HID group. Our data suggested that HID was comparable to MRD in CMML. However, under certain conditions, such as CPSS lower-risk ones, HID was preferred.

International Journal of CancerVol. 157(7)
Zhejiang Chinese Medical University (CN), Central South University (CN), University of Electronic Science and Technology of China (CN), Army Medical University (CN), Xinjiang Medical University (CN), Second Military Medical University (CN), Shanghai Jiao Tong University (CN), Jilin University (CN), Hong Kong University of Science and Technology (HK), Peking University (CN), Sichuan University (CN), Wenzhou Medical University (CN), First Affiliated Hospital of Wenzhou Medical University (CN), First Affiliated Hospital of Xinjiang Medical University (CN), Zhengzhou University (CN), West China Hospital of Sichuan University (CN), People's Liberation Army 401 Hospital (CN), Changhai Hospital (CN), Guangzhou First People's Hospital (CN), Xinqiao Hospital (CN), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN), Zhujiang Hospital (CN), Peking University People's Hospital (CN), First Hospital of Jilin University (CN), Peking University Shenzhen Hospital (CN), Peking University First Hospital (CN), Henan Provincial People's Hospital (CN), Shanghai First People's Hospital (CN), University of Hong Kong - Shenzhen Hospital (CN), Henan Cancer Hospital (CN), Guangdong Academy of Medical Sciences (CN), Jiangsu Province Hospital (CN), Shandong Provincial QianFoShan Hospital (CN), Guangdong Provincial People's Hospital (CN), Tang Du Hospital (CN), First Affiliated Hospital of Zhengzhou University (CN), Third Xiangya Hospital (CN), Xiangya Hospital Central South University (CN), Tongji Hospital (CN), Qilu Hospital of Shandong University (CN), Shandong First Medical University (CN), First Affiliated Hospital Zhejiang University (CN), Huazhong University of Science and Technology (CN), Southern Medical University (CN), Nanjing Medical University (CN), South China University of Technology (CN), Guangzhou Medical University (CN), Air Force Medical University (CN)
National Natural Science Foundation of China, Capital Health Research and Development of Special Fund, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province
Good health and well-being
Openalex Percentile: Top 5%
Acute Myeloid Leukemia Research
5.31
DOISourceOpenAlex
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