Genomic landscape of paired primary and peritoneal metastatic lesions in gastric cancer highlights evolutionary dynamics and mutational drivers
Our study elucidates clonal evolution in gastric cancer peritoneal metastasis, identifies mutational drivers, and highlights potential therapeutic targets. These findings provide valuable insights for developing precise treatment strategies for gastric cancer patients with peritoneal metastasis.
Authors
- Jianyuan Zhou
- Xinyu Song (ORCID: https://orcid.org/0000-0002-3861-1320)
- Ying Sun (ORCID: https://orcid.org/0000-0002-4076-051X)
- Chunyan Ji (ORCID: https://orcid.org/0000-0003-4438-1768)
- Xuanyu Zhou (ORCID: https://orcid.org/0000-0002-9503-7767)
- Zhaodi Nan
- Fan Jiang (ORCID: https://orcid.org/0000-0002-1145-1304)
- Xuehui Wu (ORCID: https://orcid.org/0000-0002-3911-5994)
- Wenli Zhao (ORCID: https://orcid.org/0000-0001-6152-1692)
- Song Li (ORCID: https://orcid.org/0009-0000-8528-1590)
- Liping Dou (ORCID: https://orcid.org/0000-0001-7352-9560)
- Lian Liu (ORCID: https://orcid.org/0000-0001-5868-4482)
- Huan Wang (ORCID: https://orcid.org/0000-0003-1585-6760)
- Di Zhang (ORCID: https://orcid.org/0000-0002-2342-5779)
- Weiwei Zhang (ORCID: https://orcid.org/0000-0002-3153-9389)
- Qian Xu (ORCID: https://orcid.org/0000-0002-9180-3487)
- Xin Dai (ORCID: https://orcid.org/0000-0002-1097-5253)
- Jin Jiao (ORCID: https://orcid.org/0000-0001-8450-4369)
- Jiahui Chu (ORCID: https://orcid.org/0000-0003-2949-1491)
- Xiangyong Liu (ORCID: https://orcid.org/0000-0003-1834-8403)
- Shuhan Li (ORCID: https://orcid.org/0000-0003-2461-7606)
- Qiao Hu
- Qian Yang (ORCID: https://orcid.org/0000-0002-6111-8411)
- Shulun Nie
- Shuang Wang
Institutions
- Qingdao University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qilu Hospital of Shandong University (CN)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.jare.2025.05.043
- Citations
- 3
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province